2024 Thbs4 reporter mouse

Thbs4 reporter mouse

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August undefined, 2024

Web16 Sep 2010 · Thrombospondin-4 (THBS4) is a member of the extracellular calcium-binding protein family and is involved in cell adhesion and migration. The aim of this study was to evaluate the potential role of deregulation of THBS4 expression in colorectal carcinogenesis. Of particular interest was the possible silencing of expression by methylation of the CpG … Web26 Sep 2016 · Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its susceptibility to muscular dystrophy through organization of membrane attachment complexes. Loss of the Thbs4 gene causes spontaneous dystrophic changes …

Resident Evil 4 Fans Keep Drawing Ashley as a Tiny Mouse, and …

Web8 Jun 2012 · Thbs4 coexpression enhanced Gal4 reporter activity of Atf6α fusions containing amino acids 370–670 and 370–589, but not 370–468, suggesting a minimal region of 468–589 as the interacting domain in Atf6α ... Mouse Thbs4 cDNA was generated from RNA from the hearts of 6-month old calcineurin transgenic mice (Molkentin et al., ... Web1 Jul 2014 · The mouse strain B6.129P2-Thbs4 tm1Dgen/J (Thbs4 KO in C57BL/6 background) was obtained from The Jackson Laboratory (Bar Harbor, Maine, USA). In this strain, the Thbs4 gene was inactivated by replacing 14 nucleotides in the first intron with a LacZ-neomycin resistance cassette ... booking cyprus

A Thrombospondin-Dependent Pathway for a Protective ER

Web1 Jul 2024 · (A) shows an image of an aorta from an Ang II-treated WT mouse and (B) from Ang II-treated Thbs4 −/− mouse (scale bars: 200 μm). (C) H/E staining of an aortic dissection found in Ang II-treated Thbs4 −/− mice and detail (D). (E) reveals that the hematoma is inside the media, as an elastic lamina is visible all around, shown in black by ... Web8 Jan 2024 · In skeletal muscle, overexpression of Thbs4 dramatically enhanced sarcolemmal stability that rescued mouse models of muscular dystrophy through a mechanism involving enhanced integrin and... http://www.informatics.jax.org/assay/MGI:3639251 go down the slide in spanish

Single-cell analysis uncovers fibroblast heterogeneity and …

Thrombospondin 4 deficiency in mouse impairs neuronal …

WebView In situ reporter (knock in) gene expression results for Thbs4 with structure, expression level, image, reference. Web28 Jun 2024 · Thrombospondin-4 (Thbs4) is protective in cardiac and skeletal muscle, where it activates an adaptive endoplasmic reticulum (ER) stress response, induces expansion of the ER, and enhances sarcolemmal stability. booking cycladesWebThbs4 Mouse Gene Details thrombospondin 4 International Mouse Phenotyping Consortium Gene: Thbs4 MGI:1101779 Not currently registered for phenotyping at IMPC Phenotyping is currently not planned for a knockout strain of this gene. Gene Summary … booking cyprus athens

"WebWe focused our attention on Thrombospondin 4 (Thbs4), one of the 5 members of the Thrombospondin family of large, multidomain, extracellular matrix proteins. In post-natal and adult brain Thbs4 mRNA and protein are specifically expressed in the neurogenic regions, … " - Thbs4 reporter mouse

Thbs4 reporter mouse

Thrombospondin-4 is a putative tumour-suppressor gene in …

WebGold-standard specificity, sensitivity, and reproducibility Designed to detect virtually any transcript Best-coverage assays available to detect the highest number of transcript variants possible Performance guaranteed Already know your target of interest? Search for a pre-designed TaqMan Gene Expression Assay using the tool below. Gene Expression Web1 Apr 2016 · Thbs4 is upregulated in wire-injured mouse arteries and correlated with CD68 expression. Macrophage recruitment is lower in adipose tissue and neointima of Thbs4/ApoE double knockout mice. Thbs4 ablation inhibits neointimal lesion formation in vivo following wire-induced vascular injury.

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Web22 Jun 2024 · THBS4 is overexpressed both in HCC tissues and cell lines. The overexpression of THBS4 in HCC patients’ samples in contrast to normal samples was first discovered by analysis of StarBase v3.0 (Figure 1A, P = 4.0e-36), which result was … Web2 days ago · If you're a Resident Evil 4 fan or are at all following the game online, you might have noticed some goofy art over the last month involving the character Ashley looking strangely rodent-like ...

Web23 Jan 2024 · We recently reported that TSP-4 promotes angiogenesis 24, 25 and vascular inflammation in a mouse atherosclerosis model 14. These observations suggested that TSP-4 may play an important role in... Web8 Jan 2024 · Human and mouse Thbs4 contain a RGD domain in the third type-3 repeat 60, ... The Thbs3 β-galactosidase reporter mouse strain was created from ES cell clone 19211A-A12, generated by Regeneron Pharmaceuticals, Inc. and obtained from the KOMP …

WebThrombospondin 4 Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene. [5] [6] The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and … WebDescription: LS-F7671 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse THBS4 / Thrombospondin 4 in samples of Cell Culture Supernatants, Cell Lysates, Plasma and Tissue Homogenates. It is based upon a …

WebThbs4 - thrombospondin 4 (house mouse) Predicted to enable several functions, including fibronectin binding activity; heparin binding activity; and laminin-1 binding activity. Involved in behavioral response to pain; regulation of tissue remodeling; and response to …

Web24 Jun 2024 · Mechanistically, Thbs1 binds and activates the endoplasmic reticulum stress effector PERK, inducing its downstream transcription factor ATF4 and causing lethal autophagy-mediated cardiac atrophy.... booking cypr pafosWebComplete information for THBS4-AS1 gene (RNA Gene), THBS4 Antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression. ... Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932 ... Epitope Tag Antibodies & Reporter Protein Antibodies; Lentiviral ORF ... go down the slideWeb1 May 2024 · The inhibition of THBS4 may provide therapeutic benefits that can prevent the formation of abdominal adhesions. ... Studying the roles of mouse Sox10 by conditional gene targeting. go down the slide gameWeb1 Jul 2014 · The mouse strain B6.129P2-Thbs4 tm1Dgen/J (Thbs4 KO in C57BL/6 background) was obtained from The Jackson Laboratory (Bar Harbor, Maine, USA). In this strain, the Thbs4 gene was inactivated by replacing 14 nucleotides in the first intron with a … booking cyprus limassolWebAnti-THBS4 Antibody Products. Anti-THBS4 antibodies are offered by a number of suppliers. This target gene encodes the protein 'thrombospondin 4' in humans and may also be known as TSP4 and TSP-4. Structurally, the protein is reported to be 105.9 kilodaltons in mass. Based on gene name, canine, porcine, monkey, mouse and rat orthologs may also ... bookingdance.ruWeb2 Dec 2015 · 1. Mouse models. Thbs4-deficient mice on a C57Bl/6 genetic background were purchased from the Jackson Laboratories (#005845).Their genotyping was performed with the primers 5´-GGG TGG GAT TAG ATA AAT GCC TGC TCT-3´, 5´-GGA GAG AGA ATA GCA AGA TCA GCT C-3´, and 5´-AAC AAG CAA TGG AAG GCA GAC CCT G-3´, giving rise to a … booking d1 theory test booking cypress orlando