PTGS2 (COX-2) is unexpressed under normal conditions in most cells, but elevated levels are found during inflammation. PTGS1 (COX-1) is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in the kidneys. Inhibition of PTGS1 (COX-1) reduces the basal production of cytoprotective PGE2 and PGI2 in the stomach, which may contribute to gastric ul… WebMar 21, 2024 · PTGS2 (Prostaglandin-Endoperoxide Synthase 2) is a Protein Coding gene. Diseases associated with PTGS2 include Gastric Ulcer and Bursitis . Among its related pathways are Biosynthesis of DPAn-3 SPMs and Fatty acid metabolism . Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and lipid binding .
Frontiers Comprehensive analysis of a novel RNA modifications …
WebFeb 10, 2024 · Radiation therapy is a common treatment method for cancer, whereas radioresistance of cancer cells is a huge clinical problem. 21 Tumor radioresistance is a major reason for decreased efficiency of cancer radiation therapy. 22 Through the bioinformatics analysis of differential gene expression, PTGS2 was found highly … WebApr 25, 2024 · The PTGS2 (COX-2) pathway is a promising target for cancer therapy and chemoprevention. PTGS2 (COX-2) expression in colon cancer has been inversely … diane tober tucson instagram
PTGS2 - My Cancer Genome
WebJul 7, 2024 · We have previously shown that targeting either tumor-intrinsic or myeloid cell Ptgs2 modulates immune infiltration and relieves immunosuppression, resulting in tumor growth inhibition, in a mouse model of breast cancer (64–67) As shown by others, genetic ablation of PGE 2-producing enzymes suppresses the growth of melanoma cells in mice … WebOct 14, 2011 · PTGS2 (COX-2) is an immediate-early response gene normally absent from most cells but is induced mainly at sites of inflammation in response to inflammatory … WebJan 16, 2014 · Regulators of apoptosis have been targeted with small molecules to induce cell death in cancer cells (Cotter, 2009 ). Recently, regulated, nonapoptotic cell death processes have been discovered, including necroptosis ( Degterev et al., 2005) and ferroptosis (Dixon et al., 2012 ). citgo martin luther king