Phenytoin water solubility
WebSodium phenytoin cannot be administered by intramuscular (IM) injection. Its water-soluble prodrug, fosphenytoin, is formulated in a purely aqueous solution at a pH of about 8.5; it has shown superior safety compared to sodium phenytoin while also permitting IM dosing. WebDilantin (phenytoin sodium injection, USP) is a ready-mixed solution of phenytoin sodium in a vehicle containing 40% propylene glycol and 10% alcohol in water for injection, adjusted to pH 12 with sodium hydroxide. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is
Phenytoin water solubility
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WebAmong all the mixed-solvent systems, the solubility of phenytoin was greatest in the mixed-solvent system composed of 80% v/v PEG and 20% v/v water, which presented the … Websoluble in water”; • lactose is listed as “freely soluble in water”. Since the API phenytoin (the active) is “freely soluble in water”, the lactose (excipient filler) would serve to increase the “wetting” of the active, thereby enhancing the dissolution of the active, which consequently lead to increased
WebAn older but time-tested strategy is the design of bioreversible, more water-soluble derivatives of the problematic molecule, or prodrugs. This review explores the use of prodrugs to effect improved oral and parenteral delivery of poorly water-soluble problematic drugs, using both marketed as well as investigational prodrugs as examples. WebDec 3, 2012 · Phenobarbital is a weak acid (pKa = 7.3) that is sparingly soluble in water (1 mg/ml). Phenobarbital sodium salt (PB-Na) has a better water solubility than phenobarbital per se (free acid) and consequently, has been used in phenobarbital parenteral preparations.
WebJan 15, 2024 · Peak phenytoin concentrations occur 20 to 35 minutes after the completion of the infusion. Fosphenytoin is a water-soluble prodrug of phenytoin that can be … WebPhenytoin C15H12N2O2 CID 1775 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
WebApr 1, 1999 · Fosphenytoin is a sodium monophosphate ester derivative of phenytoin sodium. The incorporation of the phosphate ester results in an aqueous solubility of 142 mg/ml which is over 4000 times the water solubility of phenytoin. Fosphenytoin has no known pharmacologic activity prior to conversion to phenytoin. thomas burnett post officeWebOct 1, 2024 · Phenytoin Sodium Injection, USP is a sterile solution of 50 mg Phenytoin Sodium per milliliter for intravenous or intramuscular administration. The solution is in a … ue fits operating instructionsWebPhenytoin sodium C15H11N2NaO2 CID 657302 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... ue fits headphonesWebJul 11, 2024 · National Center for Biotechnology Information thomas burnett post office bloomington mnWebPhenytoin 57-41-0 > 99 4. First-aid measures General Advice If symptoms persist, call a physician. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists, uefi und legacy opromWebtherefore reduce the water solubility of the drug. The most prominent example of a pH-related reduction in solubility is dilution of phenytoin sodium injection. The drug is formulated with non-aqueous solubilising agents and the solution is adjusted to a pH of 12. Dilution of injectable phenytoin by adding it to an infusion bag lowers its pH and thomas burns attorney batavia nyWebApr 20, 2009 · Phenytoin is a white, odorless powder at room temperature (Ak-ron 2009). It is practically insoluble in water, but it is soluble in ace-tone, ethanol, and alkali hydroxides … thomas burnett jr