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Ints13 function

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WebJul 24, 2007 · Function. function. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs ... INTS13 Q9NVM9: 16: EBI-4409724, EBI-741429: Expand table. Protein-protein interaction databases. BioGRID. 123520 101 interactors; ComplexPortal. CPX-6441 Integrator complex; WebJun 28, 2024 · Europe PMC is an archive of life sciences journal literature.

(PDF) INTS10–INTS13–INTS14 form a functional module

WebHome; Genomes. Human GRCh38/hg38; Human GRCh37/hg19 WebJun 1, 2024 · Similarly, INTS13 represents an independent submodule targeted to poised enhancers [52]. Understanding the structural modularity and assembly of the complex, as well as its interaction with RNAPII (Box 1) will further enhance our understanding of Integrator functions and allow identification of potential interfaces for therapeutic … cvc short a phrases

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WebAug 23, 2024 · The structure of INTS13-INTS14 reveals a strongly entwined complex with a unique chain interlink. Unexpected structural homology to the Ku70-Ku80 DNA repair complex suggests nucleic acid affinity. Indeed, the module displays affinity for DNA and RNA but prefers RNA hairpins. While the module plays an accessory role in snRNA … WebABSTRACTOral-facial-digital syndromes (OFD) are a heterogeneous group of congenital disorders characterized by malformations of the face and oral cavity, and digit anomalies. To date, mutations in 12 ciliary-related genes have been identified that WebIn the second chapter, I show that INTS13 functions as an independent submodule of Integrator and regulates enhancer activation in monocyte-macrophage differentiation. I reveal that INTS13 associates with NAB2 and the transcription factor EGR1 to activate poised enhancers, eliciting chromatin looping and gene activation. cvc short passage

Patrick Torbey École Normale Supérieure 5 Publications 48 ...

Targeted Enhancer Activation by a Subunit of the Integrator …

WebINTS10 INTS13 INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module Kevin Sabath 1, Melanie L. Stäubli 1, Sabrina Marti 1, Alexander Leitner 2, Murielle ... WebINTS13 (ASUN, C12orf11, FLJ10637, Mat89Bb, NET48, SPATA30) Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue ... cvc short i medial soundWebNov 3, 2024 · Characterization of Integrator module INTS10-INTS13-INTS14 and its connection to the cleavage module Part II. 2024-03-11. CASP XL-MS target T0987: ... This website requires cookies, and the limited processing of your personal data in … cvc short i words

"WebNX_Q9NVM9 - INTS13 - Integrator complex subunit 13 - Function. Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component … " - Ints13 function

Ints13 function

INTS13 protein (Crocodylus porosus) - STRING interaction network

WebDetect, measure, and explore your target protein's identity and function using our products: peptides, recombinant proteins, antibodies, ELISA kits, NGS, and more. All Cell Cycle Antibodies Research Areas - ABclonal WebJul 9, 2024 · Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional Integrator module. The structure of INTS13-INTS14 reveals a strongly entwined complex with a unique chain interlink.

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WebIlluminating how chemicals affect human health. Comparative Toxicogenomics Database. Home. About Us; Citing/Publications/Use; Data Status; Changes; Personnel; Funding; Legal Notices WebMar 21, 2024 · GeneCards Summary for INTS13 Gene. INTS13 (Integrator Complex Subunit 13) is a Protein Coding gene. Diseases associated with INTS13 include Germ Cell Tumor and Juvenile Type Testicular Granulosa Cell Tumor . Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of …

WebJul 5, 2024 · Integrator is a general activator of transcription at coding genes and is required for eRNA maturation. Here, we show that INTS13 functions as an independent sub-module and targets enhancers through Early Growth Response (EGR1/2) TFs and their co-factor NAB2. INTS13 binds poised monocytic enhancers eliciting chromatin looping and … WebSep 1, 2024 · In addition, Barbieri and colleagues showed that INTS13 functions as an independent submodule to mediate activation of monocytic enhancers through EGR1 and NAB2. Other INT subunits, including INTS11, INTS1, and …

WebARTICLE OPEN INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the. ... INTS14 Form a Functional Module of Integrator That Binds Nucleic Acids and the Cleavage Module [PDF] Related documentation.

WebJul 9, 2024 · Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional Integrator module. The structure of INTS13-INTS14 reveals a strongly entwined complex with a unique chain interlink. Unexpected structural homology to the Ku70-Ku80 DNA repair complex suggests nucleic acid affinity. cheapest bottled water philippinesWebThe authors show that the INTS10-inTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting and suggests that it brings cleavage module and target transcripts into proximity. The Integrator complex processes 3′-ends of spliceosomal small nuclear RNAs (snRNAs). Furthermore, it regulates transcription of … cheapest bottle of primeWebCROSS-REFERENCE TO RELATED APPLICATIONS. This application is a Continuation of U.S. patent application Ser. No. 16/649,732, filed Mar. 23, 2024, which is a national stage filing u cheapest bottled water ukWebINTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module Kevin Sabath1, Melanie L. Stäubli1, Sabrina Marti1, Alexander Leitner 2, Murielle ... cheapest bottled water pricesWebBergfort A, Preußner M, Kuropka B, Ilik İA, Hilal T, Weber G, Freund C, Aktaş T, Heyd F, Wahl MC. cheapest bottle of dom perignonWebEnhancers are cis-regulatory books in the human that cooperative with promoters to control target genetische transfer. Unlike promoters, enhancers have not requires adjacent to destination genes and can exert their actions regardless of enhancer orientations, positions and spatial segregations from target genes. Thus, for a long choose, to question as to … cvc short stories printableWebGene target information for Ints13 - integrator complex subunit 13 (house mouse). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. cheapest bottle of pappy van winkle