Web4-Octyl itaconate ≥98% (HPLC) Synonym (s): β-Monooctyl itaconate, 3- [ (Octan-4-yloxy)carbonyl]but-3-enoate, 4-Octyl methylenesuccinate, n-Octyl 3-carboxy-3-butenoate Empirical Formula (Hill Notation): C13H22O4 CAS Number: 3133-16-2 Molecular Weight: 242.31 Pricing and availability is not currently available. Properties próba ≥98% (HPLC) … Web4-Octyl Itaconate effectively prevents NP cells from degeneration through anti-ROS and anti-inflammation, and the combined use with tBHQ has better effects. In vivo: 4-Octyl …
衣康酸盐 3133-16-2 - ChemicalBook
WebNov 15, 2024 · The expression of IRG1 is predominantly restricted to macrophages and several other immune cell types and is markedly upregulated on stimulation with TLR ligands , thereby leading to an increase in intracellular itaconate. 4-Octyl itaconate (4-OI) is a cell-permeable derivative that is commonly used in the study of itaconate and has … WebOct 2, 2024 · SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate David Olagnier, Ensieh Farahani, Jacob... duke energy time of use program
Four-octyl itaconate activates Nrf2 cascade to protect …
WebSep 17, 2024 · Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1’s cysteine residues. Here, we tested … WebFeb 28, 2024 · Moreover, 4-octyl itaconate (4-OI), which is a permeable itaconate derivative, can alkylate cysteine sites 65, 71, 88, and 147 of STING, thereby inhibiting its phosphorylation. Furthermore, itaconate and 4-OI inhibit the production of inflammatory factors in sepsis models. WebDec 1, 2024 · The current study innovatively used 4-octyl itaconate (OI), a cell-permeable derivative of an endogenous anti-inflammatory metabolite itaconate (IA), to regulate the polarization of macrophages and enhance the quality of bone repair. Chitosan (CS) was selected as a bridge in coating OI on demineralized bone matrix (DBM) scaffold to … duke energy time of use