Webchlorthalidone was associated with greater reductions in blood pressure, less left ventricular hypertrophy, and lower mortality than hydrochlorothiazide.10 In a meta-analysis of 108 clinical trials with hydrochlorothiazide and 20 with chlorthalidone, in the lower dose ranges (12.5–25.0 mg), chlorthalidone produced greater reductions of blood ... WebA large VA clinical trial found that the blood pressure drug chlorthalidone (CTD) was not superior to hydrochlorothiazide (HCTZ) for the prevention of cardiovascular disease or non-cancer...
Thiazide diuretics for the treatment of high blood pressure
WebThiazide diuretics are a class of drugs commonly recommended as first-line treatment for raised blood pressure because they significantly reduce death, stroke and heart attacks. This class includes bendrofluazide, chlorthalidone, cyclopenthiazide, hydrochlorothiazide, indapamide and metolazone. WebOct 14, 2013 · Chlorthalidone has beneficial effects on important clinical outcomes in hypertensive patients (SHEP trial for instance). Thus it is an efficacious and useful treatment for hypertension. What is less clear, however, is whether chlorthalidone is better than HCTZ in terms of reducing CV, or other, clinical endpoints. japanese american treatment during ww2
Comparison of Cardiovascular and Safety Outcomes of Chlorthalidone …
WebChlorthalidone reduces systolic Blood Pressure 10 mmHg more than Hydrochlorothiazide; Shorter Half-Life (6-12 hours) than the 24 hour half life of Chlorthalidone and Indapamide. Immediate release Hydrochlorothiazide may only reduce daytime systolic Blood Pressure; Controlled release Hydrochlorothiazide (available … WebWe use the term “thiazide” in this report to indicate either chlorthalidone or HCTZ as a single-drug product. Study setting. The VHA is an integrated health-care system that uses a team-based model for care. 18 In 2004, new HCTZ prescriptions outnumbered new chlorthalidone prescriptions by over 50-fold in the VHA. 17. WebOct 3, 2024 · Common side effects of chlorthalidone may include: low blood pressure (feeling light-headed); kidney problems; dizziness; or. an electrolyte imbalance (such as low levels of potassium, sodium, or magnesium in your blood). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. japanese american women during world war ii