WebFeb 28, 2024 · Inflammation has recently been attributed to dysbiosis of the gut microbiome, which has been linked to proteinuria in chronic kidney disease. Since Adriamycin® (ADR) is widely used to induce proteinuria in mouse models, the aim of this study was to explore the potential effect of gut microbiome on this process. Both ADR resistant (C57BL/6) and … WebSep 12, 2014 · Doxorubicin (Dox) (1 mg/kg i.p., daily, for 17 days), used as the positive control, also inhibited tumor growth and tumor weight significantly (p < 0.001 and p < 0.001, Figure 3). Doxorubicin (Dox) is one of the most widely used antitumor drugs against a lot of solid tumors, including melanoma.
Analysis of Models of Doxorubicin-Induced Cardiomyopathy in …
WebAdriamycin (ADR)-induced nephropathy has been the leading model used to study human primary focal segmental glomerulosclerosis (FSGS), a common pathway for podocyte … WebThis experiment was designed to explore the optimal dose and frequency of doxorubicin-induced cardiomyopathy in a mouse model.Methods: Forty 8-10-week-old male C57BL/6J mice were randomly divided into 4 groups (control group and 3 model groups). The model group was divided into model 1 (M1) group (15 mg/kg, single dose) and M2 group (5 mg/ … cara buat template di after effects
Mild electrical stimulation with heat shock attenuates renal …
WebJun 3, 2024 · Modern Concepts of the Pathogenesis of Doxorubicin Cardiomyopathy It is assumed that the main mechanisms of action of anthracyclines are as follows: they are easily captured by cells and localized in the nucleus. DOX has an ability to inhibit DNA biosynthesis by DNA intercalation. WebDec 23, 2010 · Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease that has been studied extensively and has enabled a greater understanding of the processes underlying the progression of chronic proteinuric renal disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis. WebAdriamycin Nephropathy (AN) Rodent Model. Adriamycin was first discovered to elicit renal failure in 1977. At present, adriamycin is a well-known inducer of renal injury and … brk fire alarm keeps beeping